We investigate the role of genetic variants in predisposing individuals to obesity and related metabolic disturbances in the adipose tissue and hypothalamus. By identifying specific gene regulatory elements, genes and pathways involved in adiposity regulation, we strive to develop targeted therapeutic strategies for weight management.

​Adipose tissue is a highly dynamic endocrine organ that exhibits sexual dimorphism in its distribution, function, and gene expression profiles. We study the genetic underpinnings of sex-specific differences in adipose tissue biology, including adipocyte differentiation, lipogenesis, lipolysis, and adipokine secretion, to understand their impact on obesity development and metabolic outcomes.

We are dedicated to translating our findings into real-world applications by developing targeted CRIPSR gene therapy that can effectively address the challenges associated with adiposity and metabolic disorders.